• CSIR - Central Salt & Marine Chemicals Research Institute
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Dr. Pramod B. Shinde
Group Member

Sr.Scientist

  • pramodshinde@csmcri.res.in
  • 2567760 | Ext: 6472

Natural Products and Green Chemistry Division

Qualification
Academic Qualifications

Research
Research Activities

Isolation and structure determination of secondary metabolites utilizing chromatographic separation and spectroscopic analysis (1D and 2D NMR and MS, MS/MS, HR-MS), Isolation and identification of symbiotic microorganisms

-|| Research Highlights ||-

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    1. Pradipkumar Vaghela; Khanjan Trivedi; K G Vijay Anand; Pramod B. Shinde; Arun kumar Das,  Arup Ghosh. Characterization and Metabolomics Profiling of Kappaphycus alvarezii seaweed extract. Algal Research, 2022, communicated.
    2. Yedukondalu Nalli‡, Sanju Singh‡, Apexa Gajjar, Vishal A. Ghadge, Pankaj Kumar, Asmita Dhimmar, Harshal Sahastrabudhe, Pramod B. Shinde*; Balillibactin class siderophores as antimycobacterial agents produced by the endophyte Bacillus subtillis NPROOT3. Natural Products Research, 2022, communicated. [IF: 2.86]
    3. Tapan Kumar Maity, Nripat Singh, Pradip Vaghela, Arup Ghosh, Sanju Singh, Pramod B. Shinde, Rosy Alphons Sequeira, Kamalesh Prasad; Efficient isolation of keratin from protein rich waste biomass: A practical option to treat waste biomass. Journal of Cleaner Production. Under review. [IF: 9.29]
    4. Dilipkumar Pal, In-ho Song, Shrikant Dashrath Warkad, Keum-soo Song, Gyu Seong Yeom, Supriyo Saha, Pramod B. Shinde*, Satish B. Nimse*; Indazole-Based Microtubule Targeting Agents as Potential Candidates for Anticancer Drugs Discovery, Bioorganic Chemistry, Under review. [IF: 5.27]
    5. Durga Prasad Behera, Kapilkumar Ingle*, Doniya Elze Mathew, Asmita Dhimmar, Harshal Sahastrabudhe, Sunil Kumar Sahu*, M. Gobala Krishnan, Pramod B. Shinde*, M. Ganesan, Vaibhav A. Mantri*; Epiphytism, diseases and grazing in seaweed aquaculture: A comprehensive review. Reviews in Aquaculture, 2022, In Press https://doi.org/10.1111/raq.12653. [IF: 10.59]
    6. Vishal A. Ghadge, Pankaj Kumar, Tapan Kumar Maity, Kamalesh Prasad*, Pramod B. Shinde*; A facile alternative sustainable process for the extraction and purification of microbial melanin. ACS Sustainable Chemistry & Engineering, Accepted [IF: 8.1]
    7. Rosy Alphons Sequeira, Matheus Pereira, Pradip Vaghela, Apoorv Bhayani, Asmita Dhimmar, Dolly Maru, Arup Ghosh, Dinesh Kumar R., Pramod B. Shinde, Sanak Ray, Kamalesh Prasad; Sustainable production of quaternary ammonium seaweed polysaccharide salts and their evaluation for seed dressing in agricultural applications. ACS Agricultural Science & Technology, 2021, 1(6), 674-683. https://doi.org/10.1021/acsagscitech.1c00159
    8. Jung-Seop Lee, In-ho Song, Shrikant Dashrath Warkad, Yeom Gyu Seong, Pramod B. Shinde, Keum-soo Song, Satish B. Nimse; Synthesis and evaluation of 2-Aryl-1H-benzo[d]imidazole derivatives as potential microtubule targeting agents. Drug Development Research, https://doi.org/10.1002/ddr.21909. [IF: 4.36]
    9. Gyu Seong Yeom, In-ho Song, Shrikant Dashrath Warkad, Pramod B. Shinde, Taewoon Kim, Satish Balasaheb Nimse; Development of a novel benzimidazole-based probe and portable fluorimeter for the detection of cysteine in human urine. Biosensors, 2021, 11, 420. [IF: 5.51] https://doi.org/10.3390/bios11110420
    10. Sanju Singh, Satish B. Nimse, Doniya Elze Mathew, Asmita Dhimmar, Harshal Sahastrabudhe, Apexa Gajjar, Vishal Ghadge, Pankaj Kumar, Pramod B. Shinde*; Microbial Melanin: Recent advances in biosynthesis, extraction, characterization, and applications. Biotechnology Advances, 2021, 53, 107773. https://doi.org/10.1016/j.biotechadv.2021.107773. [IF: 14.22] ISSN 0734-9750
    11. Sanju Singh, Vishal Ghadge, Pankaj Kumar, Doniya Elze Mathew, Asmita Dhimmar, Harshal Sahastrabudhe, Yedukondalu Nalli, Mina R Rathod, Pramod B. Shinde*; Biodiversity and Antimicrobial Potential of Bacterial Endophytes from Halophyte Salicornia brachiata. Antonie van Leeuwenhoek, 2021, 114, 591-608. [IF: 2.67] https://doi.org/10.1007/s10482-021-01544-4
    12. Vishal Ghadge, Pankaj Kumar, Sanju Singh, Doniya Elze Mathew, Sourish Bhattacharya, Satish B. Nimse, Pramod B. Shinde*; Natural melanin produced by the endophytic Bacillus subtilis 4-NP-BL associated with the halophyte Salicornia brachiata. Journal of Food and Agricultural Chemistry, 2020, 68, 6854-6863. [IF: 5.27] https://doi.org/10.1021/acs.jafc.0c01997
    13. Jung-Seop Lee, In-ho Song, Pramod B. Shinde, Satish Balasaheb Nimse; Macrocycles and Supramolecules as Antioxidants: Excellent Scaffolds for Development of Potential Therapeutic Agents. Antioxidants 2020, 9, 859; [IF: 6.31] https://doi.org/10.3390/antiox9090859
    14. Jung-Seop Lee, Shrikant D. Warkad, Pramod B. Shinde, Anil Kuwar, Satish Balasaheb Nimse; A highly selective fluorescent probe for nanomolar detection of ferric ions in the living cells and aqueous media. Arabian Journal of Chemistry, 2020, 13, 8697-8707. [IF: 5.16] https://doi.org/10.1016/j.arabjc.2020.09.061
    15. Pramod B. Shinde, Hong-Se Oh, Hyemin Choi, Kris Rathwell, Yeon Hee Ban, Eun-Ji Kim, Inho Yang, Dong Gun Lee, David H. Sherman, Han-Young Kang, Yeo Joon Yoon; Chemoenzymatic synthesis of glycosylated macrolactam analogues of macrolide antibiotic YC-17. Advanced Synthesis and Catalysis 2015, 357, 2697-2711. [IF: 6.01]
    16. Pramod B. Shinde, Yeon Hee Ban, Jae-yeon Hwang, Yumi Cho, Yi-Ahn Chen, Eunji Cheong, Sang-Jip Nam, Ho Jeong Kwon, Yeo Joon Yoon; A non-immunosuppressive FK506 analogue with neuroregenerative activity from a genetically engineered Streptomyces strain. RSC Advances 2015, 5, 6823−6828. [IF: 3.36]
    17. Pramod B. Shinde, Ah Reum Han, Jaeyong Cho, So Ra Lee, Yeon Hee Ban, Young Ji Yoo, Eun Ji Kim, Eunji Kim, Dong Gun Lee, Yeo Joon Yoon; Combinatorial biosynthesis and antibacterial evaluation of 12-membered macrolide antibiotic YC-17. J. Biotech. 2013, 168, 142−148. [IF: 3.30]
    18. Yeon Hee Ban, Pramod B. Shinde, Jae-yeon Hwang, Myoung-Chong Song, Dong Hwan Kim, Si-Kyu Lim, Jae Kyung Sohng, Yeo Joon Yoon; Characterization of FK506 biosynthetic intermediates involved in post-PKS elaboration. J. Nat. Prod. 2013, 76, 1091−1098. (joint first author) [IF: 4.05]
    19. Ah Reum Han, Pramod B. Shinde, Je Won Park, Jaeyong Cho, So Ra Lee, Yeon Hee Ban, Young Ji Yoo, Eun Ji Kim, Eunji Kim, Sung Ryeol Park, Byung-Gee Kim, Dong Gun Lee, Yeo Joon Yoon; Engineered biosynthesis of glycosylated derivatives of narbomycin and evaluation of their antibacterial activities. Appl. Microbiol. Biotech. 2012, 93, 1147−1156. (joint first author) [IF: 4.81]
    20. Huayue Li, Pramod B. Shinde, Hye Ja Lee, Eun Sook Yoo, Chong-O. Lee, Jongki Hong, Sang Ho Choi, Jee H. Jung; Bile acid derivatives from a sponge-associated bacterium Psychrobacter sp. Arch. Pharm. Res. 2009, 32, 857–862. (joint first author) [IF: 4.94]
    21. Mohamed Elbandy, Pramod B. Shinde, Yoon Mi Lee, Jongki Hong, Kyung Sook Bae, Jee H. Jung; a-Pyrones and Yellow Pigments from a sponge-Derived Fungus Paecilomyces lilacinus. Bull. Korean Chem. Soc. 2009, 30, 188–192. (joint first author) [IF: 0.96]
    22. Taeseong Park, Tayyab Ahmed Mansoor, Pramod B. Shinde, Jongki Hong, Baoquan Bao, Jee H. Jung; New Cerebrosides from a Marine Sponge Haliclona (Reniera) sp. Chem. Pharm. Bull. 2009, 57, 106–111. [IF: 1.64]
    23. Pramod B. Shinde, Yoon Mi Lee, Hung The Dang, Jongki Hong, Chong-O. Lee, Jee H. Jung; Cytotoxic Bromotyrosine Derivatives from a Two Sponge Association of Jaspis sp. and Poecillastra sp. Bioorg. Med. Chem. Lett. 2008, 18, 6414–6418. [IF: 2.82]
    24. Pramod B. Shinde, Taeseong Park, Dong-Kyoo Kim, Jongki Hong, Chong-O. Lee, Chung Ja Sim, Jee H. Jung; New Glycerides from a Two Sponge Association of Jaspis sp. and Poecillastra sp. Pharm. Biol. 2008, 46, 814–818. [IF: 3.50]
    25. Pramod B. Shinde, Hung The Dang, Huayue Li, Jongki Hong, Sook Shin, Jee H. Jung; Chemical Investigation of the Sea Cucumber Stichopus japonicus. Nat. Prod. Sci. 2008, 14, 12–15. [IF: 1.71] 
    26. Mohamed Elbandy, Pramod B. Shinde, Hung The Dang, Jongki Hong, Kyung Sook Bae, and Jee H. Jung; Furan Metabolites from a Marine-Derived Yeast Pichia membranifaciens. J. Nat. Prod. 2008, 71, 869–872. [IF: 4.05]
    27. Hung The Dang, Hye Ja Lee, Eun Sook Yoo, Pramod B. Shinde, Yoon Mi Lee, Jongki Hong, Eun Sook Yoo, Jee H. Jung; Antiinflammatory Constituents of the Red Alga Gracilaria verrucosa and Their Synthetic Analogues. J. Nat. Prod. 2008, 71, 232–240. [IF: 4.05]
    28. Pramod B. Shinde, Mi Ae Kim, Byeng Wha Son, Chong-O. Lee, Jee H. Jung; Apocarotenoids from an Association of Two Marine Sponges. Nat. Prod. Sci. 2007, 13, 365–368. [IF: 1.71] 
    29. Tayyab A. Mansoor, Pramod B. Shinde, Xuan Luo, Jongki Hong, Chong-O. Lee, Chung Ja Sim, Byeng Wha Son, Jee H. Jung; Renierosides, Cerebrosides from a Marine Sponge Haliclona (Reniera) sp. J. Nat. Prod. 2007, 70, 1481–1486. [IF: 4.05]
    30. Pramod B. Shinde, Tayyab A. Mansoor, Xuan Luo, Jongki Hong, Chong-O. Lee, Jee H. Jung; Cytotoxic Polyketides from the Marine Sponge Discodermia calyx. Bull. Kor. Chem. Soc. 2007, 28, 990–994. [IF: 0.96]
    31. Jee H. Jung, Pramod B. Shinde, Jongki Hong, Yonghong Liu, Chung Ja Sim; Secondary Metabolites from a Marine Sponge Discodermia calyx. Biochem. Syst. Ecol. 2007, 35, 48–51. [IF: 1.31]
    32. Xuan Luo, Famie Li, Pramod B. Shinde, Jongki Hong, Chong-O. Lee, Kwang Sik Im, Jee H. Jung; 26,27-Cyclosterols and Other Polyoxygenated Sterols from a Marine Sponge Topsentia sp. J. Nat. Prod. 2006, 69, 1760–1768. [IF: 4.05]
    33. Yonghong Liu, Pramod B. Shinde, Jongki Hong, Chong-O. Lee, Kwang Sik Im, Jee H. Jung; Trisoxazole Macrolide from a Marine Sponge Sarcotragus Species. Nat. Prod. Sci. 2005, 11, 50–53. [IF: 1.71] 

    1. A process for the production of pure melanin from endophytic actinomycete        Streptomyces sp. MTCC 25318. Pramod B. Shinde, Kamalesh Prasad, Vishal    Ghadge, Pankaj Kumar. Indian Patent Application No. 202111002834 date of Filing 20/01/2021. (CSIR-IPU Ref No. 0078NF2020).
    2. A simple process for the extraction of lipopeptides and separation of surfactin and fengycin homologs from Bacillus sp. and use thereof. Pramod B. Shinde, Kamalesh Prasad, Yedukondalu Nalli, Sanju Singh, Harshal Sahastrabudhe, Apexa Gajjar. Patent submitted to CSIR IPU center, Delhi.
    3. Water-soluble melanin from endophytic microorganism and process thereof. Pramod B. Shinde, Vishal Ghadge, Pankaj Kumar. Patent submitted.
    4. Process for the preparation of sprayable Aqueous Chitin Solutions Fortified with   Plant Macronutrients. Prasad, Kamalesh; Singh, Nripat; Sharma, Gyanendra;      Ghosh, Arup; Meena, Ramavatar; Shinde, Pramod B. Provisional patent application No. 201911026412 filed on 02/07/2019 (CSIR-IPU Ref No. 154NF2018).
    5. Process for The Conversion of Poly(Ethylene Terephthalate) Waste Bottles to Biodegradable Solutions suitable for agriculture applications. Prasad, Kamalesh; Singh, Nripat; Ghosh, Arup; Shinde, Pramod B. Provisional Patent No. IN201811046311 filed on 20/12/2018. (CSIR-IPU Ref No : 138NF2018)
    6. FK506 derivatives maintaining nerve regeneration activity and use thereof. Yoon, Yeo Joon; Kwon, Ho Jeong; Ban, Yeon Hee; Shinde, Pramod B. US patent US 10,226,446 (12.03.2019); China patent CH 201580041277.1 (25.01.2017); Europian patent EP 15827244.3 (20.02.2017); PCT Patent WO 2016018117 A1 (37.07.2015); Korean patent KR 10-2016-0068904 (02.06.2016).
    7. Novel macrolactam glycoside derivatives, their preparation and chemical-enzymatic antimicrobial composition comprising the same, Yoon, Yeo Joon; Kang, Han Yeong; Lee, Dong Kwon; Shinde, Pramod B. Korean patent KR 10-1721750 (24.03.2017).
    8. Nerve regeneration activity of FK506 derivatives and their use without Immunosuppression. Yoon, Yeo Joon; Kwon, Ho Jeong; Ban, Yeon Hee; Shinde, Pramod B. Korean Patent Registration No. 10-1694879 (2017.01.04) / Korean Patent Application No. 10- 2014-0099210 (2014.08.01)

  • PRESENTATIONS (CONFERENCES / INVITED TALKS / POSTER) in last 5 years:

    1. Pramod B. Shinde; “Engineering biosynthesis of glycosylated derivatives of macrolide antibiotics”, presented at Bioprocessing India 2014, Institute of Chemical Technology Mumbai, December 17-20, 2014 at Mumbai, India.

    2. Shiying Jin, Pramod B. Shinde, Yeon Hee Ban, Hea Lyung Shin, Jaeyeon Hwang, Eun Young Ahn, Hang Soo Cho, Yeo Joon Yoon; "Engineered Biosynthesis of Glycosylated Derivatives: 12-Membered Macrolide Antibiotic YC-17" Presented at Korean Society of Biological Chemistry 2014 International Symposium and Annual Meeting, October 30-31, 2014 at KINTEX, Ilsan, Korea

    3. Hea Lyung Shin, Pramod B. Shinde, Yeon Hee Ban, Eunji Kim, Jaeyeon Hwang, Shiying Jin, Jin A Jung, Yeo Joon Yoon "Structural Characterization of Cyclosporine A, C and Microbial Bio-converted Cyclosporine A Analog AM6, Using HPLC-ESI-ion Trap-mass Spectrometry" Presented at Korean Society of Microbiology and Biotechnology 2014 International Symposium and Annual Meeting, June 25-27, 2014 at BEXCO, Busan, Korea

    4. Jaeyeon Hwang, Pramod B. Shinde, EunJi Kim, Hea Lyung Shin, Shiying Jin, Eun Young Ahn, Hang Soo Cho, Yeo Joon Yoon; "Elucidation of Post-Polyketide Synthase Modification Enzymes in FK506 Biosynthetic Pathway" Presented at The 7th Japan-Korea Chemical Biology Symposium, February 09-11, 2014 at The-K JEJU Hotel, Jeju-do, Korea.

    5. EunJi Kim, Pramod B. Shinde, Young Ji Yoo, Heqing Cui, Myoun Su Kim, Ji Yoon Beom, Yeo Joon Yoon; “Combinatorial biosynthesis of the glycosylated derivatives of anthracycline anticancer by using a substrate flexible glycosyltransferase”, presented at International Meeting of the Federation of Korean Microbiological Societies, October 17-18, 2013 at The-K Seoul Hotel, Seoul, South Korea.

    6. Heqing Cui, Young Ji Yoo, Eun Ji Kim, Hea Lyung Shin, Ji Yoon Beom, Pramod B. Shinde, Yeo Joon Yoon; “Post-PKS modification steps of FK506 biosynthesis”, presented at Korean Society of Biotechnology and Bioengineering Fall Meeting and International Symposium, October 16-18, 2013 at BEXCO, Busan, South Korea.

    7. Pramod B. Shinde; “Natural products drug discovery through biosynthetic pathway engineering”, presented at Department of Chemistry, Indian Institute of Technology Delhi, on August 13, 2013 at Delhi, India.

    8. Jaeyeon Hwang, Pramod B. Shinde, Dinesh Koju, Yeon Hee Ban, Eun Young Ahn, Hang Soo Cho, Yeo Joon Yoon; “Regulation of FK506 production in Streptomyces sp. Strain KCTC 11604BP”, presented at Korean Society of Microbiology and Biotechnology 2013 International Symposium and Annual Meeting, July 03-05, 2013 at Alpensia, Pyeongchang, South Korea.

    9. Eun Young Ahn, Pramod B shinde, Young Ji Yoo, Eunji Kim, Jae Yeon Hwang, Heqing Cui, Myoun Su Kim, Yeo Joon Yoon; "Generation of narbomycin derivatives and their antibacterial activity tests”, presented at 2013 Korean Society of Biotechnology and Bioengineering Spring Meeting and International Symposium, April 10-12, 2013 at at K. D. J. Center, Kwangju, South Korea.

    10. Pramod B. Shinde, Ah Reum Han, Jaeyong Cho, So Ra Lee, Yeon Hee Ban, Young Ji Yoo, Eun Ji Kim, Eunji Kim, Je Won Park, Dong Gun Lee, Yeo Joon Yoon; “Combinatorial biosynthesis and antibacterial evaluation of glycosylated derivatives of 12-membered macrolide antibiotic YC-17”, presented at 15th International Biotechnology Symposium and Exhibition (IBS-2012) Innovative Biotechnology for Green World and Beyond, September, 17-21, 2012 at Daegue, South Korea.

    11. Pramod B. Shinde; “Drug discovery: Natural products chemistry meets microbial biotechnology”, presented at Department of Biological Environment, College of Agriculture and Life Science, Kangwon National University, on December, 16, 2011 at Chuncheon, South Korea.

    12. Ji Yeon Park, Sung Ryeol Park, Pramod B. Shinde, Young Ji Yoo, Eun Ji Kim, Yeo Joon Yoon; “Enhanced flavonoid production in Streptomyces venezuelae via metabolic engineering”, presented at 2011 Korean Society of Biotechnology and Bioengineering Fall meeting and international symposium, October 05-08, 2011 at Songdo Convensia, Incheon, South Korea

  • Natural Products Drug Discovery: Potential drug leads from marine and terrestrial resources (plants, microorganisms, sponges, corals, tunicate, starfish, etc), Natural Products Biosynthesis: Elucidation of biosynthetic pathways, Chemical ecology: Microbe-plant, microbe-marine invertebrate, and microbe-insect symbiosis
  • Isolation and structure determination of secondary metabolites utilizing chromatographic separation and spectroscopic analysis (1D and 2D NMR and MS, MS/MS, HR-MS), Isolation and identification of symbiotic microorganisms
  • Others