• CSIR - Central Salt & Marine Chemicals Research Institute
  • G20
Devices & Sensors

Title of Process/ Know-how/ Product/Design/Equipment

Homocysteine specific optical sensor for diagnostic use

  • IPR
    IPR Status & Details:
  • IN 202011038506
Application/Uses/Problem being addressed

Direct measurement (fluorimetric) of cardiovascular disease marker homocysteine in human blood plasma

Salient Technical Features including Competing Features/ Impact
  • Optical sensor for measuring homocysteine directly and selectively in human plasma.
  • Proof-of-concept has been established with spiked human blood samples.
  • Clinical validation of the optical sensor has been performed with cardiac patient samples.
  • Cell-line based bio-imaging and toxicity (MTT) data available.
  • Gold standard validation of the developed sensors for sensitivity and specificity.
    • TRL Level & Scale of Development:
    TRL 4

    Lab level (gram scale)

    Business scope & opportunity (in terms of scale, cost, market etc.):

    Measurement of homocysteine concentration in human blood functions as the single largest risk marker for heart diseases and strokes. Indian market desperately looking for indigenous point-of-care assay for measuring plasma homocysteine with extreme specificity. No indigenous kit is available in India to measure homocysteine directly in human plasma. All available kits are imported and can only perform indirect measurement. We, at CSIR-CSMCRI, have developed a sensor that can measure homocysteine with absolute specificity in human plasma directly.

    Environmental Considerations:

    N/A

    Status of Licensing:
    Not yet licensed
    Status of Commercialization:
    Not applicable
    Major Raw Materials Needed

    Hydroxycoumarin, hexamine, acetic acid, diethyl ether, substituted diamine, copper nitrate, and methanol.

    Major Plant Equipment and Machinery Required

    None

    Techno-Economics

    Available on request

    Technology Package

    Know-how for homocysteine specific optical sensor; Demonstration of the synthesis of probe and diagnostic process; License fee and other financial details are available on request.