• CSIR - Central Salt & Marine Chemicals Research Institute
  • G20
Salt and Marine Chemicals

Title of Process/ Know-how/ Product/Design/Equipment

A process for pharma-grade sodium chloride

  • IPR
    IPR Status & Details:
  • Patent filed
Application/Uses/Problem being addressed

The process is to manufacture pharm-grade salt. Main uses are in pharmaceutical industry. Pharmaceutical grade sodium chloride has many applications in injections, hemodialysis, oral rehydration salts (ORS), channeling agents/ osmotic agent, and dietary formulations etc.

Salient Technical Features including Competing Features/ Impact
  • It is a combination of chemical and physical method to separate the impurities to get the pharma-grade salt.
  • The process does not use expensive BaCl2 which is toxic in nature.
  • This process can be scaled-up as a continuous process without the necessity of time-consuming recrystallization step.
  • The production cost is less to sustain in the market.
  • Complies with the specifications of IP grade
    • TRL Level & Scale of Development:
    TRL 4

    Technology validated in lab scale at Kg level in CSIR-CSMCRI ESF/ pilot plant

    Business scope & opportunity (in terms of scale, cost, market etc.):

    Few companies have approached us for discussion regarding commercialization scope with capacity in the range ~250 ton/month. As there are no major manufacturer of pharmaceutical sodium chloride in India, indigenous process developed can fulfill both domestic need and offers export potential.

    Environmental Considerations:

    The process is environmentally friendly. The solid by-product magnesium hydroxide along with other metal hydroxides can be used for derive other magnesia chemicals.

    Status of Licensing:
    Ready for licensing
    Status of Commercialization:
    Not applicable
    Major Raw Materials Needed

    Raw NaCl (sea/subsoil brine), NaOH/CaO/Na2CO3

    Major Plant Equipment and Machinery Required

    Brine tank with agitator, Nutsche filter, single/Multi-stage evaporator, ultrafiltration unit, centrifuge, process pump, dryer

    Techno-Economics

    Production cost of the salt will be around ₹6-7/kg.

    Technology Package

    Technical specification of each component, design drawing & layout, installation & commissioning, demonstration, basic training for the process (SOP). License fee and other financial details would be provided on request.