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Organic chemicals including pharmaceuticals

Title of Process/ Know-how/ Product/Design/Equipment

Catalytic process for the preparation of isolongifolene

Application/Uses/Problem being addressed
  • Iso-longifolene (C15H24), an isomeric product of longifolene (C15H24), is extensively used in perfumery, fragrance, food and pharmaceutical industries due to its woody amber odor.
  • The existing commercial method for the preparation of iso-longifolene from longifolene involves multi-step homogeneous catalytic process using corrosive liquid acid (e.g. sulfuric acid) that needs neutralization before waste disposal.
  • We have prepared iso-longifolene from longifolene in a single step in presence of a solid acid catalyst, which is eco-friendly, easily separable and re-usable.
  • Salient Technical Features including Competing Features/ Impact

    • Single step, solvent free heterogeneous green catalytic synthesis of iso-longifolene resulting into 90-95% conversion of longifolene with ~100% selectivity of iso-longifolene.

    • Use of an eco-friendly, separable and re-usable solid acid catalyst having excellent performance on re-cycling as an alternative to conventionally used homogeneous acid catalyst.

    TRL Level & Scale of Development:
    TRL 3

    The reaction has been successfully scaled up to 1 kg in liquid phase batch reactor with similar activity as that of lab scale experiments (2 g).

    Business scope & opportunity (in terms of scale, cost, market etc.):
    • Reasonable cost
    • International market
    • Imported largely from China
    Environmental Considerations:

    The process is solvent free and environment friendly using an eco-friendly, easily separable and re-usable solid acid catalyst (and an endeavor to replace conventional liquid acid catalysts (e.g. sulfuric acid))

    Status of Licensing:
    Not yet licensed
    Status of Commercialization:
    Not applicable
    Major Raw Materials Needed

    Non-toxic solvents and reagents for catalyst synthesis and longifolene

    Major Plant Equipment and Machinery Required

    Stirred batch reactor, furnace and gas chromatograph (GC)

    Techno-Economics

    The price of longifolene is ~₹130/- per kg Isolongifolene is imported mainly from China companies (Zauba.com) with varied price ranging $2 to $120 per kg, probably based on purity on scale of shipment

    Technology Package

    Green catalytic process for the synthesis of isolongifolene perfumery chemical over eco-friendly, re-usable solid acid catalyst