Title of Process/ Know-how/ Product/Design/Equipment
A process for synthesis of raspberry ketone
Application/Uses/Problem being addressed
Fruity berry-like odour; Raspberry ketones (RK) are found to be useful to burn subcutaneous fats, dietary supplements, promoting weight loss, in skin-lightening cosmetics anti-inflammatory and anti-oxidative activities.
Salient Technical Features including Competing Features/ Impact
The present synthesis protocol reports aryl ketone using acetoacetic ester and substituted benzylic alcohols/halide using inexpensive indigenous commercially available solid acid catalyst provides convenient and efficient synthetic route of alkylation and decarboxylation
High conversion and excellent selectivity
Solvent free conditions are feasible
TRL Level & Scale of Development:
Process is carried out at 50g scale
Business scope & opportunity (in terms of scale, cost, market etc.):
The market value for aryl ketones ranks second behind vanillin, with a total potential market value (US$3000/kg). However, RK is mainly isolated from red raspberries fruits, and extractable concentration of RK is very low (1-4 mg/kg); Opportunity for “Make in India”
Environmental Considerations:
No effluent is generated in the process; Use of easily filterable solid catalyst; Scope to avoid solvents
Status of Licensing:
Not yet licensedStatus of Commercialization:
Not applicableMajor Raw Materials Needed
Benzylic alcohols, Acetoacetic ester
Major Plant Equipment and Machinery Required
Process equipment like reaction vessel with agitating assembly, distillation set-up
Techno-Economics
Techno-economically attractive as the reaction occurs in single pot using an inexpensive commercial catalyst
Technology Package
Process know-how for Raspberry ketone; Demonstration of the process at 100 g scale; License fee, royalty and other financial details are available on request.
